Publications - The Marshall Lab

Pre-prints

71. Kandul NP, Liu J, Bennett JB, Marshall JM, Akbari OS (2020) A home and rescue gene drive forces its inheritance stably persisting in populations. bioRxiv doi: https://www.biorxiv.org/content/10.1101/2020.08.21.261610v2
https://www.biorxiv.org/content/10.1101/2020.08.21.261610v2.full.pdf

70. Terradas G, Buchman AB, Bennett JB, Shriner I, Marshall JM, Akbari OS, Bier E (2020) Inherently confinable split-drive systems in Drosophila.
bioRxiv doi: https://www.biorxiv.org/content/10.1101/2020.09.03.282079v1
https://www.biorxiv.org/content/10.1101/2020.09.03.282079v1.full.pdf

69. Buchman A, Shriner I, Yang T, Liu J, Antoshechkin I, Marshall JM, Perry MW, AkbariOS (2020) Engineered reproductively isolated species drive reversible population replacement. bioRxiv doi: https://www.biorxiv.org/content/10.1101/2020.08.09.242982v1
https://www.biorxiv.org/content/10.1101/2020.08.09.242982v1.full.pdf

68. Adolfi A, Gantz VM, Jasinskiene N, Lee HF, Hwang K, Bulger EA, Ramaiah A, Bennett JB, Terradas G, Emerson JJ, Marshall JM, Bier E, James AA (2020) Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi. bioRxiv doi: https://doi.org/10.1101/2020.08.02.233056
https://www.biorxiv.org/content/10.1101/2020.08.02.233056v2.full.pdf

67. Rerolle F, Dantzer E, Lover AA, Marshall JM, Hongvanthong B, Sturrock HJW, Bennett A (2020) Spatio-temporal associations between deforestation and malaria incidence in Lao PDR. medRxiv doi: https://doi.org/10.1101/2020.04.23.20072215
https://www.medrxiv.org/content/10.1101/2020.04.23.20072215v1.full.pdf

66. Jing QL, Wu SL, He Z, Yuan L, Ma M, Bai Z, Jiang L, Marshall JM, Lu J, Yang Z (2019) New genotype invasion of dengue virus serotype 1 drove massive outbreak in Guangzhou, China. bioRxiv doi: https://doi.org/10.1101/697052
https://www.biorxiv.org/content/biorxiv/early/2019/07/09/697052.full.pdf

65. Sánchez HM, Marshall JM, Wu SL, Vallejo EE (2017) Effects of spatial heterogeneity on transmission potential in vectorial-contact networks: A comparison of three Aedes aegypti control strategies. bioRxiv doi: https://doi.org/10.1101/210450
https://www.biorxiv.org/content/biorxiv/early/2017/10/28/210450.full.pdf

2020

63. Cheung C, Gamez S, Carballar-Lejarazú R, Ferman V, Vásquez VN, Terradas G, Ishikawa J, Schairer CE, Bier E, Marshall JM, James AA, Akbari OS, Bloss CS (2020) Translating gene drive science to promote linguistic diversity in community and stakeholder engagement. Global Public Health doi: https://doi.org/10.1080/17441692.2020.1779328
https://www.tandfonline.com/doi/full/10.1080/17441692.2020.1779328

62. Sánchez HM, Bennett JB, Wu SL, Rašić G, Akbari OS, Marshall JM (2020) Confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations. BMC Biology 18: 50
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-0759-9

61. Wu SL, Sánchez HM, Henry JM, Citron DT, Zhang Q, Compton KE, Liang B, Verma A, Cummings DAT, Le Menach A, Scott TW, Wilson AL, Lindsay SW, Moyes CL, Hancock PA, Russell TL, Burkot TR, Marshall JM, Kiware S, Reiner RC, Smith DL (2020) Vector bionomics and vectorial capacity as emergent properties of mosquito behaviors and ecology. PLoS Computational Biology 16: e1007446
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007446

60. James SL, Marshall JM, Christophides GK, Okumu FO, Nolan T (2020) Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing. Vector-Borne and Zoonotic Diseases doi: https://doi.org/10.1089/vbz.2019.2606
https://www.liebertpub.com/doi/full/10.1089/vbz.2019.2606

59. Friedman RM, Marshall JM, Akbari OS (2020) Gene drives: New and improved. Issues in Science and Technology 36: 72-78
https://issues.org/gene-drives/

58. Raban RR, Marshall JM, Akbari OS (2020) Progress toward engineering gene drives for population control. Journal of Experimental Biology 223: jeb208181
https://jeb.biologists.org/content/223/Suppl_1/jeb208181

57. Li M, Yang T, Kandul NP, Bui M, Gamez S, Raban R, Bennett JB, Sánchez HM, Lanzaro GC, Schmidt H, Lee Y, Marshall JM, Akbari OS (2020) Development of a confinable gene-drive system in the human disease vector, Aedes aegypti. eLife 9: e51701
https://elifesciences.org/articles/51701

56. López VD, Bishop AL, Sánchez HM, Bennett JB, Feng X, Marshall JM, Bier E, Gantz VM (2020) A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment. Nature Communications 11: 352
https://www.nature.com/articles/s41467-019-13977-7

2019

55. Pham TB, Phong CH, Bennett JB, Hwang K, Jasinskiene N, Parker K, Stillinger D, Marshall JM, Carballar-Lejarazú R, James AA (2019) Experimental population modification of the malaria vector mosquito, Anopheles stephensi. PLoS Genetics 15: e1008440
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008440

54. Zhang Z, Jing Q, Chen Z, Li T, Jiang L, Li Y, Luo L, Marshall JM, Yang Z (2019) The increasing menace of dengue in Guangzhou, 2001–2016: The most important epicenter in mainland China. BMC Infectious Diseases 19: 1002
https://link.springer.com/article/10.1186/s12879-019-4504-3

53. Marshall JM, Raban RR, Kandul NP, Edula JR, León TM, Akbari OS (2019) Winning the tug-of-war between effector gene design and pathogen evolution in vector population replacement strategies. Frontiers in Genetics 10: 1072
https://www.frontiersin.org/articles/10.3389/fgene.2019.01072/full

52. Sánchez HM, Wu SL, Bennett JB, Marshall JM (2019) MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations. Methods in Ecology and Evolution doi: https://doi.org/10.1111/2041-210X.13318
https://besjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/2041-210X.13318

51. Kandul NP, Liu J, Sánchez HM, Wu SL, Marshall JM, Akbari OS (2019) Reply to 'Concerns about the feasibility of using "precision guided sterile males" to control insects'. Nature Communications 10: 3955
https://www.nature.com/articles/s41467-019-11617-8

50. Lee Y, Schmidt H, Collier TC, Conner WR, Hanemaaijer MJ, Slatkin M, Marshall JM, Chiu JC, Smartt CT, Lanzaro GC, Mulligan FS, Cornel AJ (2019) Genome-wide divergence among invasive populations of Aedes aegypti in California. BMC Genomics 20: 204
https://link.springer.com/article/10.1186%2Fs12864-019-5586-4

49. Kandul NP, Liu J, Sánchez HM, Wu SL, Marshall JM, Akbari OS (2019) Transforming insect population control with precision guided sterile males. Nature Communications 10: 84
https://www.nature.com/articles/s41467-018-07964-7
Press:
UCSD News: New CRISPR-based technology developed to control pests with precision-guided genetics
GEN: Gene drive alternative could lead pesky insects to dead ends

2018

48. Arakala A, Hoover CM, Marshall JM, Sokolow SH, De Leo GA, Rohr JR, Remais JV, Gambhir M (2018) Empirical estimation of the effective reproduction number of schistosomiasis: Methods and implications for macroparasitic disease elimination feasibility. PLoS Neglected Tropical Diseases 12: e0006794
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006794

47. KaramiNejadRanjbar M, Eckermann KN, Ahmed HMM, Sánchez HM, Dippel S, Marshall JM, Wimmer EA (2018) Consequences of resistance evolution in a Cas9-based sex-conversion suppression gene drive for insect pest management. Proceedings of the National Academy of Sciences USA doi: https://doi.org/10.1073/pnas.1713825115
http://jmarshall.berkeley.edu/KaramiNejadRanjbar2018PNAS.pdf

46. Marshall JM, Wu SL, Sánchez HM, Kiware SS, Ndhlovu M, Ouédraogo AL, Touré MB, Sturrock HJ, Ghani AC, Ferguson NM (2018) Mathematical models of human mobility of relevance to malaria transmission in Africa. Nature Scientific Reports 8: 7713
https://www.nature.com/articles/s41598-018-26023-1

45. Jing QL, Cheng Q, Marshall JM, Hu WB, Yang ZC, Lu JH (2018) Imported cases and minimum temperature drive dengue transmission in Guangzhou, China: Evidence from an ARIMAX model. Epidemiology & Infection doi: https://doi.org/10.1017/S0950268818001176

44. Buchman A, Marshall JM, Ostrovski D, Yang T, Akbari OS (2018) Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii. Proceedings of the National Academy of Sciences USA doi: https://doi.org/10.1073/pnas.1713139115
http://www.pnas.org/content/early/2018/04/16/1713139115/
Press:
UCSD News: Researchers develop first gene drive targeting worldwide crop pest

43. Buchman A, Ivy T, Marshall JM, Akbari OS, Hay BA (2018) Engineered reciprocal chromosome translocations drive high threshold, reversible population replacement in Drosophila. ACS Synthetic Biology doi: 10.1021/acssynbio.7b00451
http://jmarshall.berkeley.edu/Buchman2018ACSSyntheticBiology.pdf

42. Marshall JM*, Akbari OS* (2018) Can CRISPR-based gene drive be confined in the wild? A question for molecular and population biology. ACS Chemical Biology 13: 424-430
*Co-corresponding authors
http://jmarshall.berkeley.edu/Marshall2018ACSChemicalBiology.pdf

41. Benedict MQ, Burt A, Capurro ML, De Barro P, Handler AM, Hayes KR, Marshall JM, Tabachnick WJ, Adelman ZN (2018) Recommendations for laboratory containment and management of gene drive systems in arthropods. Vector-Borne and Zoonotic Diseases 18: 2-13
http://online.liebertpub.com/doi/full/10.1089/vbz.2017.2121

2017

40. Kiware SS, Chitnis N, Tatarsky A, Wu SL, Sánchez HM, Gosling R, Smith DL, Marshall JM (2017) Attacking the mosquito on multiple fronts: Insights from the Vector Control Optimization Model (VCOM) for malaria elimination. PLoS ONE 12: e0187680
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187680

39. Adelman Z, Akbari OS, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Costero-Saint Denis A, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall JM, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C (2017) Rules of the road for insect gene drive research and testing. Nature Biotechnology 35: 716-718
http://jmarshall.berkeley.edu/Adelman2017NatureBiotech.pdf

38. Marshall JM*, Buchman A, Sánchez HM, Akbari OS* (2017) Overcoming evolved resistance to population-suppressing homing-based gene drives. Nature Scientific Reports 7: 3776
*Co-corresponding authors
https://www.nature.com/articles/s41598-017-02744-7
Press:
Berkeley News: New gene-editing technique could drive out mosquito-borne disease
Daily Californian: Campus researchers discover potential to reduce mosquito-borne diseases through CRISPR technology
The Scientist: Researchers propose solution to gene drive technology problem

37. Zhu L, Muller GC, Marshall JM, Arheart KL, Qualls WA, Hlaing WM, Schlein Y, Traore SF, Doumbia S, Beier JC (2017) Is outdoor vector control needed for malaria elimination? An individual-based modelling study. Malaria Journal 16: 266
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-1920-y

36. Cheng Q, Jing Q, Spear RC, Marshall JM, Yang Z, Gong P (2017) The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou. PLoS NTDs 11: e0005701
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005701

35. Killeen GF, Marshall JM, Kiware SS, Andy S, Chaki PP, Govella NJ (2017) Measuring, manipulating and exploiting behaviors of adult mosquitoes to optimize malaria vector control impact. BMJ Global Health 2: e000212
http://gh.bmj.com/content/2/2/e000212

34. Killeen GF, Tatarsky A, Diabate A, Chaccour CJ, Marshall JM, Okumu FO, Brunner S, Newby G, Williams YA, Malone D, Tusting LS, Gosling RD (2017) Developing an expanded vector control toolbox for malaria elimination. BMJ Global Health 2: e000211
http://gh.bmj.com/content/2/2/e000211

33. Killeen GF, Kiware SS, Okumu FO, Sinka ME, Moyes CL, Massey NC, Gething PW, Marshall JM, Chaccour CJ, Tusting LS (2017) Going beyond personal protection against mosquito bites to eliminate malaria transmission: population suppression of malaria vectors that exploit both human and animal blood. BMJ Global Health 2: e000198
http://gh.bmj.com/content/2/2/e000198

2016

32. Marshall JM, Bennett A, Kiware SS, Sturrock HJW (2016) The hitchhiking parasite: Why human movement matters to malaria transmission and what we can do about it. Trends in Parasitology 32: 752-755
http://jmarshall.berkeley.edu/Marshall2016TrendsParasitol.pdf

31. Marshall JM, Touré MB, Ouédraogo AL, Ndhlovu M, Kiware SS, Rezai A, Nkhama E, Griffin JT, Hollingsworth DT, Doumbia S, Govella NJ, Ferguson NM, Ghani AC (2016) Key traveller groups of relevance to spatial malaria transmission: A survey of movement patterns in four sub-Saharan African countries. Malaria Journal 15: 200
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1252-3

30. Cheng Q, Jing Q, Spear RC, Marshall JM, Yang Z, Gong P (2016) Climate and the timing of imported cases as determinants of the dengue outbreak in Guangzhou, 2014: Evidence from a mathematical model. PLoS NTDs 10: e0004417
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004417

2015

29. Marshall JM, Akbari OS (2015) Gene drive strategies for population replacement. In: Adelman ZN (editor), Genetic Control of Dengue and Malaria, Elselvier/Academic Press, New York
http://jmarshall.berkeley.edu/Chapter9GeneticControlOfDengueAndMalaria.pdf

28. Zhu L, Marshall JM, Qualls WA, Schlein Y, McManus JW, Arheart KL, Hlaing WM, Traore SF, Doumbia S, Müller GC, Beier JC (2015) Modeling optimum use of attractive toxic sugar bait stations for effective malaria vector control in Africa. Malaria Journal 14: 492
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-015-1012-9

27. Zhu L, Qualls WA, Marshall JM, Arheart KL, DeAngelis DL, McManus JW, Traore SF, Doumbia S, Schlein Y, Müller GC, Beier JC (2015) A spatial individual-based model predicting a great impact of copious sugar sources and resting sites on survival of Anopheles gambiae and malaria parasite transmission. Malaria Journal 14: 59
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-015-0555-0

26. Marshall JM (2015) Measuring public attitudes to releases of transgenic mosquitoes for disease control. In: Tyagi BK (editor), WHO/TDR Training Manual: Biosafety for Human Health and the Environment in the Context of the Potential Use of Genetically Modified Mosquitoes, WHO Press, Geneva
http://jmarshall.berkeley.edu/Chapter11WHOTrainingManualGMMs.pdf

25. Marshall JM (2015) The Cartagena Protocol and releases of transgenic mosquitoes. In: Tyagi BK (editor), WHO/TDR Training Manual: Biosafety for Human Health and the Environment in the Context of the Potential Use of Genetically Modified Mosquitoes, WHO Press, Geneva
http://jmarshall.berkeley.edu/Chapter9WHOTrainingManualGMMs.pdf

2014

24. Marshall JM, Hay BA (2014) Medusa: A novel gene drive system for confined suppression of mosquito populations. PLoS ONE 9: e102694
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102694
Press:
IGTRCN: Medusa: Harnessing a sex-linked transgenic drive system to control insect populations

23. Okorie PN, Marshall JM, Akpa MO, George AO (2014) Perceptions and recommendations by scientists for a potential release of genetically modified mosquitoes in Nigeria. Malaria Journal 13: 154
https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-154
Press:
SciDev.Net: Nigerian scientists wary of anti-malarial GM mosquitoes

22. White MT, Lwetoijera D, Marshall JM, Caron-Lormier G, Bohan DA, Denholm I, Devine GJ (2014) Negative cross resistance mediated by co-treated bed nets: A potential means of restoring pyrethroid-susceptibility to malaria vectors. PLoS ONE 9: e95640
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095640

2013

21. Marshall JM, White MT, Ghani AC, Schlein Y, Muller GC, Beier JC (2013) Quantifying the mosquito’s sweet tooth: Modeling the effectiveness of attractive toxic sugar baits (ATSB) for malaria vector control. Malaria Journal 12: 291
https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-12-291

20. Akbari OS*, Matzen KD*, Marshall JM*, Huang H, Ward CM, Hay BA (2013) A synthetic gene drive system for local, reversible modification and suppression of insect populations. Current Biology 23: 671-677
*Equal contribution
http://www.cell.com/current-biology/fulltext/S0960-9822(13)00266-2
Press:
Current Biology: Insect biotechnology: Controllable replacement of disease vectors

19. Gatton ML, Chitnis N, Churcher T, Donnelly MJ, Ghani AC, Godfray HCJ, Gould F, Hastings I, Marshall JM, Ranson H, Rowland M, Shaman J, Lindsay SW (2013) The importance of mosquito behavioral adaptations to malaria control in Africa. Evolution 67: 1218-1230
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655544/

2012

18. Marshall JM, Hay BA (2012) Confinement of gene drive systems to local populations: A comparative analysis. Journal of Theoretical Biology 294: 153-171
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260013/

17. Marshall JM, Hay BA (2012) General principles of single-construct chromosomal gene drive. Evolution 66: 2150-2166
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389707/

16. De Silva P, Marshall JM (2012) Factors contributing to urban malaria transmission in sub-Saharan Africa: A systematic review. Journal of Tropical Medicine 2012: 819563
https://www.hindawi.com/journals/jtm/2012/819563/

15. Akbari OS*, Chen CH*, Marshall JM*, Huang H, Antoshechkin I, Hay BA (2012) Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; A theoretical exploration of Medea-dependent population suppression. ACS Synthetic Biology 3: 915-928
*Equal contribution
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742681/

2011

14. Marshall JM, Pittman GW, Buchman A, Hay BA (2011) Semele: A killer-male, rescue-female system for suppression and replacement of insect disease vector populations. Genetics 187: 535-551
http://www.genetics.org/content/187/2/535
Press:
Deutsche Welle: New model may revolutionize mosquito-borne disease control
Science Daily: Pesticide-free method takes a bite out of mosquito-borne disease

13. Marshall JM, Hay BA (2011) Inverse Medea as a novel gene drive system for local population replacement: A theoretical analysis. Journal of Heredity 102: 336-341
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076586/

12. Marshall JM (2011) The toxin and antidote puzzle: New ways to control insect pest populations through manipulating inheritance. Bioengineered Bugs 2: 1-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225740/

11. Marshall JM (2011) The Cartagena Protocol in the context of recent releases of transgenic and Wolbachia-infected mosquitoes. Asia-Pacific Journal of Molecular Biology & Biotechnology 19: 93-100
http://jmarshall.berkeley.edu/MarshallAPJMBB2011.pdf

2010

10. Marshall JM (2010) The Cartagena Protocol and genetically modified mosquitoes. Nature Biotechnology 28: 896-897
http://jmarshall.berkeley.edu/Marshall2010NatureBiotech.pdf
Press:
SciDev.Net: Biosafety meeting “must address GM insects”

9. Marshall JM, Touré MB, Traore MM, Famenini S, Taylor CE (2010) Perspectives of people in Mali toward genetically modified mosquitoes for malaria control. Malaria Journal 9: 128
https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-9-128

8. Marshall JM, Touré MB, Traore MM, Taylor CE (2010) Towards a quantitative assessment of public attitudes to transgenic mosquitoes: Questions based on a qualitative survey in Mali. Asia-Pacific Journal of Molecular Biology & Biotechnology 18: 251-273
http://jmarshall.berkeley.edu/MarshallAPJMBB2010.pdf

2009

7. Marshall JM, Taylor CE (2009) Malaria control with transgenic mosquitoes. PLoS Medicine 6: e1000020
http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000020

6. Marshall JM (2009) The effect of gene drive on containment of transgenic mosquitoes. Journal of Theoretical Biology 258: 250-265
http://jmarshall.berkeley.edu/Marshall2009JTheorBiol.pdf

2008

5. Marshall JM (2008) A branching process model for the early spread of a transposable element in a diploid population. Journal of Mathematical Biology 57: 811-840
http://jmarshall.berkeley.edu/Marshall2008JMathBiol.pdf

4. Marshall JM (2008) The impact of dissociation on transposon-mediated disease control strategies. Genetics 178: 1673-1682
http://www.genetics.org/content/178/3/1673.long

2007

3. Marshall JM, Morikawa K, Manoukis N, Taylor CE (2007) Predicting the effectiveness of population replacement strategy using mathematical modeling. Journal of Visualized Experiments 5: 227
https://www.jove.com/video/227/predicting-effectiveness-population-replacement-strategy-using

2006

2. Marshall JM, Weiss R (2006) A Bayesian heterogeneous analysis of variance approach to inferring recent selective sweeps. Genetics 173: 2357-2370
http://www.genetics.org/content/173/4/2357.long

2004

1. Wills P, Marshall JM, Smith P (2004) Genetic information and self-organised criticality. Europhysics Letters 68: 901-907
http://jmarshall.berkeley.edu/Wills2004Europhysics.pdf